{"Abbreviation":[],"Aliases":["urate","Lithic acid","2,6,8-trioxypurine","2,6,8-trihydroxypurine","7,9-Dihydro-1H-purine-2,6,8(3H)-trione","2,6,8-Trioxopurine","1H-Purine-2,6,8-triol","1H-Purine-2,6,8(3H)-trione, 7,9-dihydro-","Purine-2,6,8(1H,3H,9H)-trione","2,3,6,7,8,9-hexahydro-1H-purine-2,6,8-trione","Uricum acidum","trioxopurine","Idelalisib metabolite m54","Urate, Sodium","Urate, Potassium","Urate, Monosodium","Acid, Uric","Acid Urate, Sodium","Urate, Sodium Acid","Acid Urate, Ammonium","Urate, Ammonium Acid","RefChem:6339","Uric Acid 1547","Urate Monohydrate, Sodium","Urate Monohydrate, Monosodium"],"CAS":"69-93-2","ChEBI":"CHEBI:17775","ChEMBL":"CHEMBL792","ChemicalClasses":["xanthine"],"Chirality":"achiral","Drug Indication":"At present (August 2013), there is no approved indication for uric acid.  The potential therapeutic use for uric acid is as an adjunct in acute ischemic stroke.","EINECS":"200-720-7","Esters":[],"European Community (EC) Number":"200-720-7","Formating":[],"HMDB ID":"HMDB0000289","HeavyAtomCount":12,"IUPACName":"7,9-dihydro-3H-purine-2,6,8-trione","InChI":"InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)","InChIKey":"LEHOTFFKMJEONL-UHFFFAOYSA-N","MeSH Pharmacological Classification":"Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues.","Melting Point":"Greater than 300 °C","MolecularFormula":"C\u003csub\u003e5\u003c/sub\u003eH\u003csub\u003e4\u003c/sub\u003eN\u003csub\u003e4\u003c/sub\u003eO\u003csub\u003e3\u003c/sub\u003e","MolecularWeight":"168.11 g/mol","Pharmacodynamics":"Uric acid is a strong reducing agent (donates electrons) and an antioxidant. Normally in humans, one of the main antioxidants in plasma is uric acid. Several animal studies have found that animals given exogenous uric acid within 3 hours after a stroke had decreased infarct volume, improved neurologic function, and diminished inflammatory responses providing evidence for the neuroprotective effects of uric acid. In some early human studies, uric acid has so far shown similar neuroprotective effects, in both the cortex and subcortex areas, due to its antioxidant effects such as decreased lipid peroxidation, and there appears to be no significant toxicities.","Physical Description":"White odorless solid; [Merck Index] Beige powder; [Sigma-Aldrich MSDS]","PubChemId":1175,"RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Uric_acid","Name":"Uric acid","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q105522","Name":"Uric acid","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB08844","Name":"Uric acid","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/1175","Name":"Uric acid","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL792","Name":"Uric acid","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:17775","Name":"Uric acid","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=69-93-2","Name":"Uric acid","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0000289","Name":"Uric acid","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C00366","Name":"Uric acid","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/268B43MJ25","Name":"Uric acid","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID3042508","Name":"Uric acid","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 1175, Uric acid. Accessed September 15, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/1175\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/1175\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Uric acid. UNII: 268B43MJ25. Global Substance Registration System. Accessed September 15, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/268B43MJ25\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/268B43MJ25\u003c/a\u003e"],"SMILES":"C12=C(NC(=O)N1)NC(=O)NC2=O","SaltData":[],"Salts":[],"Solubility":"0.06 mg/mL","StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 83.961 57.272\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#3050f8\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h84v58H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M42.432 41.181v-15.24M39.994 39.773V27.349\"/\u003e\u003c/g\u003e\u003cpath d=\"m42.432 41.181 11.255 3.621M59.566 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class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Title":"Uric acid","UNII":"268B43MJ25","Wikidata":"Q105522","Wikipedia":"Uric_acid","XLogP":-1.9}